<i>In vivo</i> Expansion of Regulatory T cells via an Engineered IL-2 Mutein to Suppress Autoimmune Glomerulonephritis
Collectively, these findings suggest that engineered IL-2 mutein which selectively expands Treg cells <i>in vivo</i> holds significant promise as an alternative immunotherapeutic strategy for controlling autoimmune GN while reducing nonspecific immunosuppression.
Authors
- Huang Kuang (ORCID: https://orcid.org/0000-0001-7739-291X)
- Wenxuan Li (ORCID: https://orcid.org/0009-0000-6641-0393)
- Yuge Zhu
- Ping Li
- Zhong Li
- Ming-Hui Zhao
- Xiao-Yu Jia
- Nan Li
- Cai-Xia Lin
- Jing Huang
- Nan Jiang
- Zhao Cui
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Theranostics
- Published
- 2026-02-18
- DOI
- https://doi.org/10.7150/thno.126588
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00