Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with <sup>19</sup> F MRI Feasibility (Small 11/2026)
Ultrasound-Responsive mRNA Nanocarriers In article number e6806, Mark Louis P. Vidallon, Xiaowei Wang, and co-workers introduce nanodroplets for ultrasound-guided mRNA delivery. Trackable by ultrasound and fluorine-19 magnetic resonance imaging, the nanodroplets transform into microbubbles upon acoustic activation, enabling real-time imaging and localized mRNA delivery to vascular cells with precise spatiotemporal control.
Authors
- Henry N. Gordon
- Bangyan Xu (ORCID: https://orcid.org/0000-0002-2156-9074)
- Sylvain Trépout (ORCID: https://orcid.org/0000-0002-5822-407X)
- Karlheinz Peter (ORCID: https://orcid.org/0000-0002-8040-2258)
- Ulrich Flögel (ORCID: https://orcid.org/0000-0001-7181-4392)
- Alexis I. Bishop (ORCID: https://orcid.org/0000-0001-5905-6170)
- Mitchell J. Moon (ORCID: https://orcid.org/0000-0001-9345-5001)
- Yuyang Song (ORCID: https://orcid.org/0000-0002-0973-2078)
- Mark Louis P. Vidallon (ORCID: https://orcid.org/0000-0002-0026-3906)
- Shulei Ren
- Haikun Liu (ORCID: https://orcid.org/0000-0001-8050-2737)
- Xiaowei Wang
- Pu Shi (ORCID: https://orcid.org/0009-0009-0957-1110)
- Rico Tabor
- Aidan P. G. Walsh
Institutions
- Baker Heart and Diabetes Institute (AU)
- The University of Melbourne (AU)
- La Trobe University (AU)
- Düsseldorf University Hospital (DE)
- Melbourne Health (AU)
- Heinrich Heine University Düsseldorf (DE)
- Monash University (AU)
Publication Details
- Journal
- Small
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/smll.72781
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00