Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing (Adv. Mater. 11/2026)
Mesenchymal Stem Cell-Inspired Microneedle In their Research Article (DOI: 10.1002/adma.202514081), Hyun-Do Jung, Han Young Kim and co-workers introduce a mesenchymal stem cell (MSC)–inspired microneedle that mimics adaptive MSC secretion. A dual-compartment design integrates photothermal MXene nanosheets and MSC-derived nanovesicle–DNA conjugates for near-infrared–triggered release, regulating inflammation, promoting angiogenesis, and accelerating tissue remodeling in chronic diabetic wounds. This biomimetic–nanomaterial platform enables immune-regenerative wound therapy.
Authors
- Jong‐Seo Yoon (ORCID: https://orcid.org/0000-0002-5782-6175)
- Kyung‐Yup Cha
- Han Young Kim (ORCID: https://orcid.org/0000-0002-5585-9272)
- Heemin Kang (ORCID: https://orcid.org/0000-0003-1359-2810)
- Donghyun Lim (ORCID: https://orcid.org/0000-0002-6070-198X)
- N. S. Lee
- Hyun‐Woo Lee (ORCID: https://orcid.org/0000-0002-1648-8093)
- Dongjin Lee
- Min‐Ho Kang (ORCID: https://orcid.org/0000-0002-1342-0077)
- Hee Gyeong Ko
- Su Ryon Shin
- Ju Yeong Gwon
- Soo‐Hong Lee
- Hyeong Seok Kang
- Seojoon Bang
- Yun‐A Kim
- So Won Jeon
- Gi Doo Cha
- Chan Ho Moon
- Hyun‐Do Jung
- Kisuk Yang
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Incheon National University (KR)
- Korea University (KR)
- Dongguk University (KR)
- Hanyang University (KR)
- Chung-Ang University (KR)
- Catholic University of Korea (KR)
- Korea Institute of Industrial Technology (KR)
Publication Details
- Journal
- Advanced Materials
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/adma.72363
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00