Glial Connexin-43 Is a Pathogenic Mechanism Promoting Gut Inflammation After Postsurgical Intestinal Manipulation With Potential Relevance to Humans
Glial Cx43 signaling promotes enteric gliosis, immune cell activation, inflammation, and enteric neuropathy in mice with potential translatability to humans after intestinal surgical trauma and mechanical stress in POI. Interventions that block glial Cx43 activation may be protective against POI development.
Authors
- Brian D. Gulbransen (ORCID: https://orcid.org/0000-0003-1145-3227)
- Alan Harzman (ORCID: https://orcid.org/0000-0002-5450-4998)
- Jonathon L. McClain
- Reiner Albert Schneider
- Fievos L. Christofi (ORCID: https://orcid.org/0000-0003-2773-6846)
- Patrick Leven (ORCID: https://orcid.org/0000-0002-6768-2523)
- Paolo Fadda (ORCID: https://orcid.org/0000-0001-9444-1461)
- Sven Wehner
- Alix Zuleta Alarcon
- Elvio Mazzotta
- Manekeller Steffen
- Dmitrii Pavlov
- Samhita Chaudhuri
- Yunpeng Du
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
- Michigan State University (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2026.101755
- Citations
- 1
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 39.15