The cholinergic system exerts opposing effects on memory at different stages of disease progression in Alzheimer's and Down syndrome model systems
These findings refine and challenge the cholinergic hypothesis, revealing for the first time a functional shift from cholinergic hyperactivity driving early cognitive impairment to late-stage degeneration requiring enhancement.
Authors
- Helen E. Scharfman (ORCID: https://orcid.org/0000-0003-4006-3383)
- Christos Panagiotis Lisgaras (ORCID: https://orcid.org/0000-0003-3712-5993)
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71154
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Citizens United for Research in Epilepsy
- New York State Office of Mental Health
- National Institute on Aging