The effect of combination antibiotic therapy on mortality in patients with sepsis or septic shock due to <i>Pseudomonas aeruginosa</i> bloodstream infections: a systematic review
Current evidence does not support routine use of combination therapy over monotherapy. Empirical combination therapy may be considered in carefully selected high-risk patients, with prompt de-escalation once susceptibilities are known.
Authors
- Zeynep Özer (ORCID: https://orcid.org/0000-0001-8405-1208)
- Melike Yüce Aktepe (ORCID: https://orcid.org/0000-0002-9303-7077)
- Çağlayan Merve Ayaz
- Özlem Çakin
- Mestan Emek
- Selma Turan Kavradım
Institutions
- Akdeniz University Hospital (TR)
Publication Details
- Journal
- Expert Review of Anti-infective Therapy
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1080/14787210.2026.2635427
- Primary Topic
- Nosocomial Infections in ICU
- Type
- article
- Field-Weighted Citation Impact
- 0.00