Hypertriglyceridemia During Anticancer Therapy in Pediatric Patients with Acute Lymphoblastic Leukemia – A Nationwide Experience
This is the first nationwide, multicenter analysis conducted across pediatric hemato-oncology centers in Poland evaluating HTG during ALL therapy. HTG occurred in 11.1% of children in the analyzed cohort, and 72% of these cases were grade 3 or 4. With the management strategies applied, severe complications were uncommon and chemotherapy interruptions were generally short. Our findings support the effective triglyceride monitoring; however, triglyceride measurements are currently not standardized and are not performed at predefined time points during treatment. The observed association between low antithrombin levels and high triglyceride concentrations may help identify patients who require closer surveillance. Further prospective studies are needed to define risk factors, optimize prevention and treatment strategies and explore long-term outcomes.
Authors
- Ewa Demidowicz (ORCID: https://orcid.org/0000-0002-0459-4040)
- Julia Kołodrubiec (ORCID: https://orcid.org/0000-0002-8169-1709)
- Szymon Pawel Skoczen
- Grażyna Karolczyk
- Joanna Trelińska (ORCID: https://orcid.org/0000-0003-1484-4274)
- Eryk Latoch (ORCID: https://orcid.org/0000-0002-7667-7953)
- Zuzanna Zakrzewska (ORCID: https://orcid.org/0000-0001-7595-5459)
- Mariola Janiszewska
- Jerzy Kowalczyk (ORCID: https://orcid.org/0000-0003-3080-0845)
- Katarzyna Karska (ORCID: https://orcid.org/0000-0002-0719-7243)
- Katarzyna Konończuk (ORCID: https://orcid.org/0000-0003-0540-8040)
- M Andrzejewska
- Dorota Sęga-Pondel
- Wioletta Bal
- Ninela Irga-Jaworska
- Patrycja Tyszka
- Wanda Badowska
- Katarzyna Derwich
- Krzysztof Kalwak
- Monika Lejman
- Klaudia Paczóska
- Radosław Chaber
- Tomasz Ociepa
- Anna Malecka
- Joanna Zawitkowska
- Tomasz Szczepański
Institutions
- Poznan University of Medical Sciences (PL)
- Medical University of Lublin (PL)
- Jagiellonian University (PL)
- Medical University of Silesia (PL)
- Medical University of Warsaw (PL)
- Nicolaus Copernicus University (PL)
- Medical University of Lodz (PL)
- University of Warmia and Mazury in Olsztyn (PL)
- Gdańsk Medical University (PL)
- Pomeranian Medical University (PL)
- University of Silesia in Katowice (PL)
- University of Rzeszów (PL)
Publication Details
- Journal
- Cancer Management and Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/cmar.s572651
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencja Badań Medycznych