A Rare Case of Rectal Bleeding due to Kasabach-Merritt Syndrome

Kasabach-Merritt syndrome (KMS) is a rare, life-threatening coagulopathy associated with kaposiform hemangioendothelioma and tufted angioma, typically seen in infants and rarely in adults. It is thought to result from platelet and coagulation factor sequestration within vascular lesions, leading to severe bleeding. We report a case of a 70-year-old woman with KMS presenting with rectal bleeding. Despite limited access to desmopressin, which had effectively controlled her symptoms, she experienced recurrent bleeding and ultimately succumbed to gastrointestinal hemorrhage. This case underscores the challenges of managing KMS in adults and highlights the importance of multidisciplinary coordination and consistent follow-up.

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Publication Details

Journal
ACG Case Reports Journal
Published
2026-02-01
DOI
https://doi.org/10.14309/crj.0000000000002017
Primary Topic
Vascular Malformations and Hemangiomas
Type
article
Field-Weighted Citation Impact
0.00
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article

A Rare Case of Rectal Bleeding due to Kasabach-Merritt Syndrome

Leen Hasan, Koushalya Sachdev, Steven M. Cohn, Edward Butt et al.
ACG Case Reports Journal
Vascular Malformations and Hemangiomas
article

A Rare Case of Rectal Bleeding due to Kasabach-Merritt Syndrome

Leen Hasan, Koushalya Sachdev, Steven M. Cohn, Edward Butt, Raakhi Menon
article en

Abstract

Kasabach-Merritt syndrome (KMS) is a rare, life-threatening coagulopathy associated with kaposiform hemangioendothelioma and tufted angioma, typically seen in infants and rarely in adults. It is thought to result from platelet and coagulation factor sequestration within vascular lesions, leading to severe bleeding. We report a case of a 70-year-old woman with KMS presenting with rectal bleeding. Despite limited access to desmopressin, which had effectively controlled her symptoms, she experienced recurrent bleeding and ultimately succumbed to gastrointestinal hemorrhage. This case underscores the challenges of managing KMS in adults and highlights the importance of multidisciplinary coordination and consistent follow-up.

ACG Case Reports JournalVol. 13(2)
The University of Texas Medical Branch at Galveston (US), The University of Texas at Austin (US)
Openalex Percentile: Top 49%
Vascular Malformations and Hemangiomas
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A Rare Case of Rectal Bleeding due to Kasabach-Merritt Syndrome — Leen Hasan, Koushalya Sachdev, et al. · ACG Case Reports Journal (2026) | TGRS Research Map | TGRS