Dihydroartemisinin Alleviates Neuronal Damage and Seizures in Epileptic Mice by Inhibiting Ferroptosis via the <scp>SIRT1</scp> / <scp>FOXO1</scp> / <scp>SLC7A11</scp> / <scp>GPX4</scp> Pathway
In summary, our findings indicate that DHA may have antiepileptic and neuroprotective benefits by suppressing ferroptosis through the SIRT1/FOXO1/SLC7A11/GPX4 signaling pathway.
Authors
- Zhijie Fan (ORCID: https://orcid.org/0000-0002-8748-0224)
- Zhipeng You
- Xiaoying Gao (ORCID: https://orcid.org/0000-0001-7287-2367)
- Cong Huang (ORCID: https://orcid.org/0000-0002-1119-431X)
- Jiayu Sun (ORCID: https://orcid.org/0000-0002-0920-5948)
- Yunmin He
- Shiyi Zhao
- Fan Wei
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70798
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00