Determinants of extracellular fluid calcium concentration in patients with chronic hypoparathyroidism
The main determinant of blood calcium levels in patients with chronic hypoparathyroidism is tubular calcium reabsorption, assessed by TRCa/GFR. Alfacalcidol is effective in correcting hypocalcemia due to its tubular effect but may lead to renal complications due to its intestinal and bone effects. The use of complementary treatment with thiazide diuretics or PTH analogs, possibly guided by the calculation of TRCa/GFR, could allow a better correction of hypocalcemia in these patients.
Authors
- Élise Bouderlique (ORCID: https://orcid.org/0000-0002-7269-1424)
- Arthur Michon-Colin (ORCID: https://orcid.org/0000-0002-8678-3733)
- G. Maruani
- Pascal Houillier
- Théau Blanchard
Institutions
- Institut national de recherche en sciences et technologies du numérique (FR)
- Inserm (FR)
- General Electric (Spain) (ES)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Laboratoire National de Référence (MA)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1093/ejendo/lvag036
- Primary Topic
- Thyroid and Parathyroid Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00