The Mediating Roles of Self-Efficacy, Resilience, and Social Support in the Relationship Between Clinical Factors and Adaptation to Chronic Disease

The findings indicate a significant indirect pathway through which comorbidities and complex medication regimens are associated with adaptation via self-efficacy. Social support showed a direct, rather than mediating, association with adaptation, whereas resilience appeared to have a limited role. These results suggest that clinical practice may benefit from focusing on simplifying treatment regimens, enhancing self-management efficacy through personalized education, and mobilizing social support.