Intrathecal Isoniazid and Dexamethasone Therapy May Improve Outcomes in Patients With Tuberculous Meningitis: A 2-Center Retrospective Cohort Study
Intrathecal administration of isoniazid and dexamethasone may improve functional prognosis in TBM patients. These findings highlight IT therapy as a promising approach to circumvent the blood-brain barrier and warrant validation in multicenter randomized controlled trials.
Authors
- Xiaoqing
- Meijun Liu (ORCID: https://orcid.org/0009-0008-4567-5040)
- R Chen
- Yaojie Shen (ORCID: https://orcid.org/0009-0003-6367-1864)
- Dan Ye (ORCID: https://orcid.org/0000-0001-7161-9976)
- Huarui Liu
- Yang Ren
- Xuhui Liu
- Yang Yang
- Lu Xia
- Zhentao Fei
- Yuanyuan Chen
- Feng Li
- Meiji Wang
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Yunnan Center for Disease Control And Prevention (CN)
- Hangzhou Red Cross Hospital (CN)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2026-02-14
- DOI
- https://doi.org/10.1093/cid/ciag106
- Primary Topic
- Infectious Diseases and Tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00