Synergistic regulation of SLC7A11 and glucose-6-phosphate dehydrogenase in redox homeostasis governs decidualization: a mechanistic insight into adenomyosis-related infertility
The SLC7A11-G6PD axis cooperatively counteracted ferroptosis during decidualization. SLC7A11-G6PD downregulation in adenomyosis resulted in oxidative damage and infertility. Pharmacological targeting of this redox axis may represent a novel therapeutic strategy for restoring endometrial receptivity in adenomyosis.
Authors
- Fanxuan Zhao
- Weijia GU
- Yongdong Dai (ORCID: https://orcid.org/0000-0002-5494-6948)
- Xiaoying Jin
- Biya Zeng
- Weijie Yang
- Yingyi Zhang
- Feng Zhou
- Na Liu
- Songying Zhang
- Xiang Lin
- Xinyu Wang
- Yi Zhang
Institutions
- Sir Run Run Shaw Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.02.030
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00