The Sex-Dependent Relationship between Amygdala Activation and Depressive Symptoms with Problematic Drinking
Taken together, our findings reveal sex differences in negative emotional processing in at-risk adolescents. These associations have the potential to inform the development of sex-specific strategies as well as the detection of early neuronal risk factors to effectively curtail alcohol risk behavior.
Authors
- Laura S. Daedelow (ORCID: https://orcid.org/0000-0001-5828-2731)
- Marcus Rothkirch (ORCID: https://orcid.org/0000-0001-7545-3432)
- Gareth J. Barker (ORCID: https://orcid.org/0000-0002-5214-7421)
- E. Artiges
- Nick Ortiz
- Annika Rosenthal (ORCID: https://orcid.org/0000-0003-1320-4072)
- Hugh P. Garavan
- Rüdiger Brühl
- Nathalie Nathalie Holz
- Erik Lukas Bode (ORCID: https://orcid.org/0009-0001-6138-8040)
- Luise Poustka
- Samanda Krasniqi
- Robert Whelan
- Marie-Laure Paillère Martinot
- Michael N. Smolka
- Tobias Banaschewski
- Andreas Heinz
- Sylvane Desrivières
- Henrik Walter
- Jean-Luc Martinot
- Dimitri Papadopoulos Orfanos
- Penny Gowland
- Gunter Schumann
- Herta Flor
- Arun L.W. Bokde
- Nilakshi Vaidya
- Paul Wirsching
Institutions
- University of Vermont (US)
- Physikalisch-Technische Bundesanstalt (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Nottingham (GB)
- Inserm (FR)
- University of Mannheim (DE)
- King's College London (GB)
- Trinity College Dublin (IE)
- Heidelberg University (DE)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- University Hospital Heidelberg (DE)
- Humboldt-Universität zu Berlin (DE)
- Sorbonne Université (FR)
- MSB Medical School Berlin (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Central Institute of Mental Health (DE)
- Pitié-Salpêtrière Hospital (FR)
- CEA Paris-Saclay (FR)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Laboratoire de Biologie et Pharmacologie Appliquée (FR)
- Einstein Center for Neurosciences Berlin (DE)
- Freie Universität Berlin (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.biopsych.2026.02.007
- Primary Topic
- Substance Abuse Treatment and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- HORIZON EUROPE Framework Programme
- Medical Research Council