<scp>DNA</scp> Hypermethylation of the <scp> <i>ZNF382</i> </scp> Promoter Region and Low <scp>mRNA</scp> Expression of <scp> <i>ZNF382</i> </scp> Promote Diffuse Large B‐Cell Lymphoma Occurrence and Progression
DNA hypermethylation in the promoter region of ZNF382 and low ZNF382 mRNA expression are closely related to the occurrence and progression of DLBCL. Moreover, ZNF382 overexpression significantly increased apoptosis and inhibited cell proliferation, migration, and clone formation. Therefore, ZNF382 has potential as a therapeutic target in the treatment of DLBCL.
Authors
- Huirui Wang
- Pengli Xiao
- Emma Mi
- Sizhe Liu
- Shuli Guo
- Wanhua An
Institutions
- University of Oxford (GB)
- Lincoln University College (MY)
- Luoyang Central Hospital Affiliated to Zhengzhou University (CN)
Publication Details
- Journal
- Cancer Reports
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cnr2.70502
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00