Aperiodic Signatures of Stress Sensitivity and Depression Recurrence in Adolescents
The aperiodic slope may function as a neurophysiological diathesis that amplifies stress-related risk for depression recurrence. Findings support a diathesis-stress model of adolescent MDD and highlight the aperiodic slope as a biomarker that may guide developmentally sensitive personalized prevention strategies.
Authors
- Lilian Y. Li (ORCID: https://orcid.org/0000-0001-7507-3632)
- Mikki Schantell (ORCID: https://orcid.org/0000-0002-2972-1368)
- Katherine Durham
- Allison M. Letkiewicz (ORCID: https://orcid.org/0000-0002-6812-8735)
- Randy P. Auerbach (ORCID: https://orcid.org/0000-0003-2319-4744)
- Sarah E. Sarkas
- Madeline M. McGregor (ORCID: https://orcid.org/0009-0001-1072-7399)
- Stewart A Shankman
- Esha Trivedi
- Nayoung Kim
- David Pagliaccio
- Emma Wool
Institutions
- Northwestern University (US)
- New York Psychoanalytic Society and Institute (US)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.bpsc.2026.02.005
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00