Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut–brain endothelial dysfunction
Our findings suggest gut microbe metabolite leakage traversing the gut-blood-brain barrier in AGS, potentially because of endothelial dysfunction.
Authors
- Shrujna Patel (ORCID: https://orcid.org/0000-0003-4928-692X)
- Madysen Elbourne (ORCID: https://orcid.org/0000-0002-1994-8577)
- Michelle A. Farrar (ORCID: https://orcid.org/0000-0002-4472-0902)
- Sushil Bandodkar (ORCID: https://orcid.org/0000-0001-5000-4518)
- Josephine Yu (ORCID: https://orcid.org/0000-0002-4615-5257)
- Velda X. Han (ORCID: https://orcid.org/0000-0003-4633-4316)
- R. C. Dale
- S. Mohammad
- Jingya Yan
- Markus J Hofer
- Shanlin Fu
- Arlene D'Silva
Institutions
- University of Technology Sydney (AU)
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- National University of Singapore (SG)
- Children's Hospital at Westmead (AU)
- UNSW Sydney (AU)
- The George Institute for Global Health (AU)
- Sydney Children’s Hospitals Network (AU)
- National University Health System (SG)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cti2.70074
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Technology Sydney
- Petre Foundation
- Cerebral Palsy Alliance
- National Health and Medical Research Council