Impact of contemporary guideline-directed medical therapy on secondary mitral and tricuspid regurgitation in heart failure with reduced ejection fraction

In patients with a recent diagnosis of HFrEF receiving contemporary GDMT, the majority of patients with ≥moderate secondary MR and TR achieved regression of MR/TR, and the minority of patients without significant baseline MR/TR developed ≥moderate regurgitation at follow-up.

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Publication Details

Journal
European Journal of Heart Failure
Published
2026-02-17
DOI
https://doi.org/10.1093/ejhf/xuag047
Primary Topic
Cardiac Valve Diseases and Treatments
Type
article
Field-Weighted Citation Impact
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article

Impact of contemporary guideline-directed medical therapy on secondary mitral and tricuspid regurgitation in heart failure with reduced ejection fraction

Sorin V. Pislaru, Austin M Kennedy, Jwan A. Naser, G Lin et al.
European Journal of Heart Failure
Cardiac Valve Diseases and Treatments
article

Impact of contemporary guideline-directed medical therapy on secondary mitral and tricuspid regurgitation in heart failure with reduced ejection fraction

Sorin V. Pislaru, Austin M Kennedy, Jwan A. Naser, G Lin, David A. Foley, Paul M. McKie, Serena Joseph Rahme, Mackram F. Eleid, M Castrichini, Vuyisile T Nkomo, Hossam Ibrahim, Barry A Borlaug, Christopher G Scott
article en

Abstract

In patients with a recent diagnosis of HFrEF receiving contemporary GDMT, the majority of patients with ≥moderate secondary MR and TR achieved regression of MR/TR, and the minority of patients without significant baseline MR/TR developed ≥moderate regurgitation at follow-up.

European Journal of Heart Failure
Mayo Clinic (US), Jacksonville College (US), Mayo Clinic in Florida (US)
Openalex Percentile: Top 53%
Cardiac Valve Diseases and Treatments
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Impact of contemporary guideline-directed medical therapy on secondary mitral and tricuspid regurgitation in heart failure with reduced ejection fraction — Sorin V. Pislaru, Austin M Kennedy, et al. · European Journal of Heart Failure (2026) | TGRS Research Map | TGRS