Relevance of Chemokines in Mobilizing γδ T Cells in the Biliary Tract Cancer Microenvironment: Potential for γδ T-Cell–Based Adoptive Cell Therapy
Comprehensive single-cell analysis identified selective chemokine recruitment signatures supporting γδ T-cell infiltration but revealed paradoxical corecruitment of immunosuppressive populations. Patient stratification through chemokine profiling, combined with γδ T-cell enrichment and targeted chemokine antagonism, represents a rational therapeutic strategy.
Authors
- Saikat Mandal (ORCID: https://orcid.org/0000-0003-1250-5295)
- Manideepa Maji (ORCID: https://orcid.org/0000-0003-2839-5158)
- Guruprasad Aithal (ORCID: https://orcid.org/0000-0003-3924-4830)
- Arkadeep Dhali
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- University of Hull (GB)
- Hull University Teaching Hospitals NHS Trust (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- NIHR Imperial Biomedical Research Centre (GB)
- Nottingham Biomedical Research Centre (GB)
- Imperial College London (GB)
- Hull York Medical School (GB)
Publication Details
- Journal
- American Journal of Clinical Oncology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1097/coc.0000000000001306
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- National Institute for Health and Care Research
- NIHR Nottingham Biomedical Research Centre