Heterogeneous nuclear ribonucleoprotein L orchestrates alternative splicing critical for primordial follicle formation

This study demonstrates that hnRNPL-mediated alternative splicing is critical for primordial follicle development, and its loss leads to POI, nominating hnRNPL as a potential POI biomarker.

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Publication Details

Journal
Journal of Advanced Research
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jare.2026.02.047
Primary Topic
RNA Research and Splicing
Type
article
Field-Weighted Citation Impact
0.00
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article

Heterogeneous nuclear ribonucleoprotein L orchestrates alternative splicing critical for primordial follicle formation

Jie Cai, Hang Qi, Jian Xu, Jin-Qiao Mi et al.
Journal of Advanced Research
RNA Research and Splicing
article

Heterogeneous nuclear ribonucleoprotein L orchestrates alternative splicing critical for primordial follicle formation

Jie Cai, Hang Qi, Jian Xu, Jin-Qiao Mi, Qiao-Dan Li, Chen Zhao, Ming-Hui Xiao, Feng-Jie Hu, Wei-Hong Fan, Liangyu Jiang, Zhiyi Li, Qi Jiang, Xiao-Xia Wang, Xiao-Die Lin, Xing-Xing Dai, Si-Yu Chen, XIAO CHEN, Yu Jiang, Heng-Yu Fan
article en

Abstract

This study demonstrates that hnRNPL-mediated alternative splicing is critical for primordial follicle development, and its loss leads to POI, nominating hnRNPL as a potential POI biomarker.

Journal of Advanced Research
Zhejiang International Studies University (CN), Hangzhou Normal University (CN), North West Agriculture and Forestry University (CN), The Ohio State University (US), Zhejiang University (CN)
Zero hunger
Openalex Percentile: Top 50%
RNA Research and Splicing
DOIOpen Access PDFOpenAlex
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Heterogeneous nuclear ribonucleoprotein L orchestrates alternative splicing critical for primordial follicle formation — Jie Cai, Hang Qi, et al. · Journal of Advanced Research (2026) | TGRS Research Map | TGRS