Hypofractionated Versus Normofractionated Accelerated Radiation Therapy With or Without Cisplatin for Locally Advanced Head and Neck Squamous Cell Carcinoma (HYPNO): A Randomized, Open-Label, Phase 3, Noninferiority Trial
The HYPNO test arm schedule was shown to be noninferior with respect to both loco-regional tumor control and grade 3+ late adverse events.
Authors
- May Abdel–Wahab (ORCID: https://orcid.org/0000-0002-5415-1387)
- Pedro Rafael Martins De Marchi
- Eduardo Zubizarreta (ORCID: https://orcid.org/0000-0003-1921-4909)
- Olga Goloubeva
- Murugaiyan Nagarajan
- Yaowalak Chansilpa (ORCID: https://orcid.org/0000-0001-7026-3955)
- S. Binia
- Alexandre Arthur Jacinto (ORCID: https://orcid.org/0000-0002-6353-2202)
- Misleidy Nápoles
- E. Rosenblatt
- Kirsten I. Hopkins
- Tejpal Gupta
- Jai P. Agarwal
- Sergio Aguiar
- Sarbani Ghosh Laskar
- Søren M. Bentzen
Institutions
- University of Maryland, Baltimore (US)
- International Atomic Energy Agency (AT)
- Siriraj Hospital (TH)
- Homi Bhabha National Institute (IN)
- Mahidol University (TH)
- Tata Memorial Hospital (IN)
- Centro Hospitalario Pereira Rossell (UY)
- Instituto de Oncología y Radiobiología (CU)
- Hospital de Câncer de Barretos (BR)
- Fundación para la Investigación, Docencia y Prevención del Cáncer (AR)
- HCG Cancer Centre (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.12.056
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Atomic Energy Agency
- National Cancer Institute