DEBS-055 | Five-Year Outcomes of Coronary Artery Disease Treated Exclusively With Drug-Coated Balloons

Methods: A total of 201 patients with bifurcation lesions were treated over five years (148 men and 53 women; 26%).Patients were classified into four groups based on the treatment technique:1. Two-stent strategy (n = 101); 2. DES in the main branch + DCB in the side branch (n = 30; 22 men, 8 women); 3. DCB-only (n = 11; 9 women, 2 men); 4. DES in the main branch across the side branch (n = 57; 43 men, 14 women).Patients in Group 3 were significantly older than those in other groups (mean difference 7 years), with the highest proportion of males (p = 0.05).Clinical outcomes included restenosis, target-lesion revascularization, myocardial infarction, and all-cause mortality.Lesion distribution showed that LM/LAD/Acx bifurcations were commonly treated with either the two-stent technique or the DES/DCB strategy (45% vs. 52%), while ACx/OM bifurcations were most frequently treated with the DCB-only approach.Results: There were no statistically significant differences among the four groups regarding restenosis, reintervention rates, myocardial infarction, or mortality during follow-up.The two-stent technique remained the most frequently applied method overall.The DES/DCB combination was widely used for LM/LAD/Acx lesions, whereas the DCB-only technique was predominantly selected for ACx/OM bifurcations.Advanced age in the DCB-only group did not translate into worse clinical outcomes.Conclusion: Across a five-year experience, the four evaluated bifurcation PCI strategies demonstrated comparable clinical outcomes, supporting an individualized approach to bifurcation lesion management.Selection of DCB-only therapy in older patients and specific anatomical subsets did not adversely affect short-or mid-term results.