Comparative efficacy and safety of liraglutide versus metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric patients

In this real-world psychiatric cohort, LIRA was associated with greater short-term weight loss than MET without an increased observed frequency of AEs. ED rates varied across AOMs. These findings should be interpreted cautiously, given the observational design and short follow-up period, and require confirmation in larger, long-term studies.

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Publication Details

Journal
Therapeutic Advances in Psychopharmacology
Published
2026-02-18
DOI
https://doi.org/10.1177/20451253261419609
Primary Topic
Pharmacology and Obesity Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparative efficacy and safety of liraglutide versus metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric patients

Young Sup Woo, Won‐Myong Bahk, Won-Seok Choi, M. W. Seo et al.
Therapeutic Advances in Psychopharmacology
Pharmacology and Obesity Treatment
article

Comparative efficacy and safety of liraglutide versus metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric patients

Young Sup Woo, Won‐Myong Bahk, Won-Seok Choi, M. W. Seo, Min-Kyu Song
article en

Abstract

In this real-world psychiatric cohort, LIRA was associated with greater short-term weight loss than MET without an increased observed frequency of AEs. ED rates varied across AOMs. These findings should be interpreted cautiously, given the observational design and short follow-up period, and require confirmation in larger, long-term studies.

Therapeutic Advances in PsychopharmacologyVol. 16
Korea University Medical Center (KR), Gwangmyeong Mental Health Welfare Center (KR), Onnuri Smile Eye Clinic (KR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Catholic University of Korea (KR)
Openalex Percentile: Top 49%
Pharmacology and Obesity Treatment
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