Transcriptomic signatures of IPF in ALI-cultured airway cells and their therapeutic implications
This study defines epithelial-mesenchymal programmes of the airway mucosa at an early, diagnostic stage of IPF and demonstrates distinct drug responses at single-cell resolution. By linking airway-derived phenotypes to antifibrotic efficacy, our findings highlight the therapeutic potential of saracatinib and may inform future treatment strategies.
Authors
- Nicolas Kahn (ORCID: https://orcid.org/0000-0002-5403-8069)
- Said Alkildani (ORCID: https://orcid.org/0000-0002-2629-4102)
- Carmen Veith
- Robert Lorenz Chua (ORCID: https://orcid.org/0000-0001-5945-9957)
- Katharina Jechow (ORCID: https://orcid.org/0000-0002-3382-3527)
- Christian Conrad (ORCID: https://orcid.org/0000-0001-7036-342X)
- Marc A. Schneider (ORCID: https://orcid.org/0000-0001-8269-3821)
- Agnes W. Boots (ORCID: https://orcid.org/0000-0003-0138-0124)
- Elizabeth C. Xu
- Gelsomina Kaufhold
- Roland Eils
- Michael Kreuter
- Alexander Sudy
- Michelle Wild
Institutions
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Fudan University (CN)
- University Hospital Heidelberg (DE)
- Maastricht University (NL)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Center for Lung Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Thorax
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1136/thorax-2025-223325
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00