Collagen-Bearing Exosomes from Breast Cancer–Associated Fibroblasts Promote T-cell Dysfunction
Our data provide the first evidence that ECM proteins associate with mouse and human breast CAF-derived exosomes and directly impair T-cell activation and cytotoxicity. These findings suggest that signaling between collagen-rich CAF exosomes and T cells contribute to local and systemic T-cell dysfunction.
Authors
- Samir Jana (ORCID: https://orcid.org/0000-0002-3123-4040)
- Matthew Lawton (ORCID: https://orcid.org/0000-0002-7244-1337)
- Harold Hui (ORCID: https://orcid.org/0000-0002-9701-9570)
- Dennis Jones
- Andrew Emili
- Pin-Ji Lei
Institutions
- Boston University (US)
- Oregon Health & Science University (US)
- Massachusetts General Hospital (US)
- Center for Systems Biology (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0259
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00