Caveolar Compartmentalization of Pacemaker Signaling Ensures Stable Sinoatrial Rhythmicity Which Is Disrupted in Heart Failure
SAN pacemaking is driven by complex protein interactions within a nanoscale caveolar pacemaker signalosome. Disruption of caveolae leads to SND, demonstrating a new dimension of SAN remodeling and revealing a novel therapeutic target.
Authors
- Leonid Tyan (ORCID: https://orcid.org/0000-0001-9734-7286)
- Aleah Warden
- Timothy J. Kamp (ORCID: https://orcid.org/0000-0003-2103-7876)
- Alexey V. Glukhov (ORCID: https://orcid.org/0000-0003-2076-9688)
- Claudia P. Alvarez-Baron (ORCID: https://orcid.org/0000-0003-4352-6603)
- Stefano Morotti (ORCID: https://orcid.org/0000-0001-8679-665X)
- Roman Y. Medvedev (ORCID: https://orcid.org/0000-0003-1174-2993)
- Thomas A. Schrauth
- Daniel Turner (ORCID: https://orcid.org/0000-0001-8159-2594)
- Haibo Ni
- fang Liu
- Di Lang
- Baron Chanda
- Gail A. Robertson
- Eleonora Grandi
Institutions
- University of Wisconsin–Madison (US)
- Washington University in St. Louis (US)
- University of California, Davis (US)
Publication Details
- Journal
- JACC. Clinical electrophysiology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jacep.2026.01.003
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00