Evaluation of piperacillin-tazobactam appropriateness and underlying drivers of inappropriate prescribing in a Belgian University Hospital: a retrospective study

Our findings point out the role of an antimicrobial stewardship program in improving antibiotic use, especially in surgical units where inappropriate indication and poor notification were most common. Importantly, antibiotic treatment duration remains problematic across all hospital units. By linking patient characteristics to outcomes, our study identifies key drivers of inappropriate use, which could be further confirmed and refined in future research.