Mycosis fungoides and Sézary syndrome

Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas, arising from mature CD4⁺ memory T cells. Diagnosis is complex and relies on clinicopathological correlation, immunophenotyping and molecular clonality testing, while management is stage-adapted, with potentially curative outcomes achievable only in selected patients through allogeneic haematopoietic stem cell transplantation.