Injury-Induced Epithelial Spp1 Engages Cd44 to Promote Neutrophil Recruitment and Exacerbate Acute Kidney Injury
This study provides the first evidence that tubular cell-derived Spp1 functions as a key DAMP mediating the early recruitment of Cd44<sup>+</sup> neutrophils in AKI. By inhibiting paracrine Spp1, 5-ASA limits neutrophil migration and ameliorates renal injury, supporting its therapeutic potential in AKI. Targeting Spp1 may represent a promising new strategy for AKI treatment.
Authors
- Zijian Zhang (ORCID: https://orcid.org/0000-0002-2735-3549)
- Z H Zhao
- Xiaopeng Hu
- Runyi Wang
- Jiayu Wang
- Xin Zheng
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jir.s581725
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00