Effects of cisplatin and tamoxifen chemotherapy on peri‐implant bone remodeling around titanium implants in ovariectomized rats: An in vivo study

Dental implant surgery in patients undergoing chemotherapy is frequently approached with caution, as these pharmacological treatments can impair bone metabolism and jeopardize the integration of the implant with the bone. This study investigated whether tamoxifen, a medication widely utilized in breast cancer therapy, could potentially enhance bone healing around titanium implants, specifically when administered alongside the chemotherapeutic agent cisplatin. Utilizing a laboratory model that simulates postmenopausal bone loss, the research demonstrated that tamoxifen significantly improved both the volume and the structural quality of the bone surrounding the implants, partially mitigating the adverse effects associated with cisplatin. These findings are of clinical importance as they suggest that a history of chemotherapy should not be considered a definitive barrier to successful dental rehabilitation. Instead, with appropriate pharmacological support, dental implant procedures may be a more viable and predictable treatment option for cancer survivors than previously recognized. This research provides a foundation for clinicians to better evaluate the feasibility of oral rehabilitation in this patient population, ultimately aiming to improve their long-term oral health and quality of life.