Sclerosing Odontogenic Carcinoma: A Review of a Challenging Entity in Malignant Odontogenic Classification With a Focus on Perineural Invasion and Cellular Proliferation

This challenging entity exhibits a spectrum of malignant potential, and the current classification standard of "no metastatic potential" requires revision. In cases exhibiting diverse biological behaviors, the Ki-67 proliferation score can be used an ancillary marker for risk stratification; higher rates (e.g., > 10%-15%) may be associated with aggressive local invasion and metastatic events. Further molecular studies on aggressive "metastatic" cases are imperative to allow for identification of definitive markers that can establish SOC as a distinct entity and provide a rational basis for risk assessment and treatment.

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Publication Details

Journal
Journal of Oral Pathology and Medicine
Published
2026-02-18
DOI
https://doi.org/10.1111/jop.70125
Primary Topic
Oral and Maxillofacial Pathology
Type
article
Field-Weighted Citation Impact
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article

Sclerosing Odontogenic Carcinoma: A Review of a Challenging Entity in Malignant Odontogenic Classification With a Focus on Perineural Invasion and Cellular Proliferation

Elizabeth Ann Bilodeau, Ricardo Santiago Gomez, K Hunter, Madhu Shrestha et al.
Journal of Oral Pathology and Medicine
Oral and Maxillofacial Pathology
article

Sclerosing Odontogenic Carcinoma: A Review of a Challenging Entity in Malignant Odontogenic Classification With a Focus on Perineural Invasion and Cellular Proliferation

Elizabeth Ann Bilodeau, Ricardo Santiago Gomez, K Hunter, Madhu Shrestha, Willie F. P. van Heerden, Merva Soluk‐Tekkesin, Ronell Bologna‐Molina, Wanninayake Mudiyanselage Tilakaratne, Kelly Magliocca, Liam Robinson, Haizal Mohd Hussaini, Akinyele Olumuyiwa Adisa, Jiang Li
article en

Abstract

This challenging entity exhibits a spectrum of malignant potential, and the current classification standard of "no metastatic potential" requires revision. In cases exhibiting diverse biological behaviors, the Ki-67 proliferation score can be used an ancillary marker for risk stratification; higher rates (e.g., > 10%-15%) may be associated with aggressive local invasion and metastatic events. Further molecular studies on aggressive "metastatic" cases are imperative to allow for identification of definitive markers that can establish SOC as a distinct entity and provide a rational basis for risk assessment and treatment.

Journal of Oral Pathology and Medicine
Universidade Federal de Minas Gerais (BR), University of Liverpool (GB), Ankara University (TR), Emory University (US), University of Pittsburgh (US), Universidad de la República de Uruguay (UY), University of Ibadan (NG), University of Malaya (MY), Shanghai Ninth People's Hospital (CN), Faculdade de Ciências Médicas de Minas Gerais (BR), University of Pretoria (ZA), University of Otago (NZ), Texas A&M University (US)
Openalex Percentile: Top 51%
Oral and Maxillofacial Pathology
DOISourceOpenAlex
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Sclerosing Odontogenic Carcinoma: A Review of a Challenging Entity in Malignant Odontogenic Classification With a Focus on Perineural Invasion and Cellular Proliferation — Elizabeth Ann Bilodeau, Ricardo Santiago Gomez, et al. · Journal of Oral Pathology and Medicine (2026) | TGRS Research Map | TGRS