Baicalin attenuates cisplatin-induced cochlear hair cell damage by modulating the ROS-p38 MAPK signaling pathway
Collectively, these findings demonstrate that baicalin provides robust otoprotection against cisplatin-induced hearing loss. In vitro studies further indicate that this protective effect is associated with the attenuation of oxidative stress, maintenance of mitochondrial integrity, and inhibition of p38 MAPK-mediated apoptosis. Together, the results highlight baicalin as a promising candidate for therapeutic intervention against cisplatin-induced hearing loss.
Authors
- Q. Q. Zhang
- Chunchun Zhou
- Sisi Li (ORCID: https://orcid.org/0000-0002-2423-8289)
- Yating Wang (ORCID: https://orcid.org/0000-0003-2271-7806)
- Chuan Bu
- Chunhong Zhang
- Qian Yin
- Chunguang Dong
Institutions
- Xuzhou Medical College (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Lianyungang Oriental Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fcell.2026.1742764
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Municipal Science and Technology Bureau