Kaempferol inhibits hepatitis B virus replication via ERK/FOXO1 pathway-mediated suppression of the viral core promoter
Collectively, our results indicate that KP activates ERK-dependent FOXO1 phosphorylation, leading to transcriptional repression of the HBV Cp and thereby suppression of viral replication. These findings identify KP as a potential candidate for developing novel therapeutics against chronic HBV infection.
Authors
- Jie Dou (ORCID: https://orcid.org/0000-0003-2764-5426)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Jiefeng Ding
- Haifei Yu
- Fu Chen
- Chun Dai
- Wanyu Deng
- Bo Qin
- Min Guo
- Zhen Luo
Institutions
- Shangrao Normal University (CN)
- Boston Children's Hospital (US)
- China Pharmaceutical University (CN)
- Nanfang Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- People's Hospital of Yangzhong (CN)
- Tibetan Traditional Medical College (CN)
- Southern Medical University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fcimb.2026.1780484
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wu Jieping Medical Foundation
- National Key Research and Development Program of China