Synonymous Variants of Potential Significance Identified by a 52‐Gene Clinical Sequencing Panel in Non‐Small Cell Lung Cancer

This cohort demonstrates both expected and distinct genomic features, including novel synonymous variants in oncogenic pathways. These findings suggest regional variation in NSCLC genomics and support further study of synonymous variants in disease progression.

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Publication Details

Journal
Genes Chromosomes and Cancer
Published
2026-02-01
DOI
https://doi.org/10.1002/gcc.70111
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
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article

Synonymous Variants of Potential Significance Identified by a 52‐Gene Clinical Sequencing Panel in Non‐Small Cell Lung Cancer

Kathleen Varty, Doha Itani, Crispin Russell, James C.R. Michael et al.
Genes Chromosomes and Cancer
Lung Cancer Treatments and Mutations
article

Synonymous Variants of Potential Significance Identified by a 52‐Gene Clinical Sequencing Panel in Non‐Small Cell Lung Cancer

Kathleen Varty, Doha Itani, Crispin Russell, James C.R. Michael, Jeanette E. Boudreau, Robert D. Thompson, Cenk Acar, Daniel Gaston, Leah K. MacLean, Monowar Hossain, Brian Johnston, Trisha Daigle‐Maloney, Tony Reiman
article en

Abstract

This cohort demonstrates both expected and distinct genomic features, including novel synonymous variants in oncogenic pathways. These findings suggest regional variation in NSCLC genomics and support further study of synonymous variants in disease progression.

Genes Chromosomes and CancerVol. 65(2)
University of New Brunswick (CA), Dalhousie University (CA), Saint John Regional Hospital (CA), Nova Scotia Health Authority (CA), Beatrice Hunter Cancer Research Institute (CA)
Good health and well-being
Openalex Percentile: Top 49%
Lung Cancer Treatments and Mutations
DOIOpen Access PDFOpenAlex
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Synonymous Variants of Potential Significance Identified by a 52‐Gene Clinical Sequencing Panel in Non‐Small Cell Lung Cancer — Kathleen Varty, Doha Itani, et al. · Genes Chromosomes and Cancer (2026) | TGRS Research Map | TGRS