Glymphatic system dysfunction in temporal lobe epilepsy with hippocampal sclerosis: MRI-based evaluation of circulatory markers and disease progression
This study offers substantiated evidence of GS function in patients with TLE-HS using multiple MRI-derived indices of GS function. Moreover, longer disease duration was significantly associated with lower DTI-ALPS indices, higher FW-WM levels, and enlarged CPV, while reduced HPV was closely linked to decreased DTI-ALPS and increased CPV. These findings indicate that MRI-derived GS indices may serve as potential imaging biomarkers of disease chronicity in TLE-HS.
Authors
- Xiaomei Yue
- Yuna Chen
- Hui Ning Florinda Chu
- Senhui Qiu (ORCID: https://orcid.org/0000-0002-0266-0112)
- Dingwen Hu (ORCID: https://orcid.org/0000-0001-5062-459X)
- Kun Wang (ORCID: https://orcid.org/0000-0001-9851-7080)
- Jie An
- Ziyu Diao
- Yingpeng Kuang
- Rongyu Zhang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fnins.2026.1741257
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangzhou University of Chinese Medicine
- Guangzhou University