Lysosome <scp>pH</scp> Dynamics in Physiology and Disease: Molecular Mechanisms and Therapeutic Insights

By highlighting pHlys as a nodal point in cellular functions, this review underscores the relevance of pHlys as a diagnostic marker and therapeutic target. Restoring pHlys in diseases offers translational potential to re-establish proteostasis and limit associated pathologies.

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Publication Details

Journal
Acta Physiologica
Published
2026-02-18
DOI
https://doi.org/10.1111/apha.70160
Primary Topic
Calcium signaling and nucleotide metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Lysosome pH Dynamics in Physiology and Disease: Molecular Mechanisms and Therapeutic Insights

Diane L Barber, Sonia Infante‐Tadeo
Acta Physiologica
Calcium signaling and nucleotide metabolism
article

Lysosome pH Dynamics in Physiology and Disease: Molecular Mechanisms and Therapeutic Insights

Diane L Barber, Sonia Infante‐Tadeo
article en

Abstract

By highlighting pHlys as a nodal point in cellular functions, this review underscores the relevance of pHlys as a diagnostic marker and therapeutic target. Restoring pHlys in diseases offers translational potential to re-establish proteostasis and limit associated pathologies.

Acta PhysiologicaVol. 242(3)
University of California, San Francisco (US)
Openalex Percentile: Top 50%
Calcium signaling and nucleotide metabolism
DOISourceOpenAlex
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Lysosome <scp>pH</scp> Dynamics in Physiology and Disease: Molecular Mechanisms and Therapeutic Insights — Diane L Barber, Sonia Infante‐Tadeo · Acta Physiologica (2026) | TGRS Research Map | TGRS