Characterization of phage AbpL with a terminally redundant genome and its therapeutic potential against drug-resistant Acinetobacter baumannii infections
Owing to its strong lytic activity, environmental stability, and robust <i>in vitro</i> and <i>in vivo</i> efficacy, AbpL represents a highly promising candidate for the treatment of MDR-AB infections. Furthermore, its unique 400-bp terminal redundancy may serve as a valuable platform for future engineering via synthetic biology approaches.
Authors
- Kexin Zhang (ORCID: https://orcid.org/0000-0001-9138-5134)
- Yong Li (ORCID: https://orcid.org/0000-0003-4038-0493)
- Qingqing Du
- Weiwei Jiang
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-5246-5497)
- Di Li
- Defeng Liu
- Yan Qian
Institutions
- Southwest Research Institute (US)
- Army Medical University (CN)
- Dalian Medical University (CN)
- Southwest Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fcimb.2026.1760018
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00