Cochlear neural functional competence: an integrative transcriptomic module analysis of excitability, plasticity and microenvironmental support programs

CNFC is a transparent, hypothesis-generating framework for summarizing cochlear neuronal functional state from transcriptomic data, complementing traditional survival metrics. By prioritizing interpretable modules and standardized within-dataset scoring, CNFC supports cross-study integration and highlights candidate programmes for mechanistic testing.

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Publication Details

Journal
Frontiers in Cellular Neuroscience
Published
2026-02-19
DOI
https://doi.org/10.3389/fncel.2026.1776907
Primary Topic
Hearing, Cochlea, Tinnitus, Genetics
Type
article
Field-Weighted Citation Impact
0.00
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article

Cochlear neural functional competence: an integrative transcriptomic module analysis of excitability, plasticity and microenvironmental support programs

Baojun Wu, Yong Li, Junli Wang, Li Guo et al.
Frontiers in Cellular Neuroscience
Hearing, Cochlea, Tinnitus, Genetics
article

Cochlear neural functional competence: an integrative transcriptomic module analysis of excitability, plasticity and microenvironmental support programs

Baojun Wu, Yong Li, Junli Wang, Li Guo, Yuqi Feng, Ying Gao, Xiaoyong Ren
article en

Abstract

CNFC is a transparent, hypothesis-generating framework for summarizing cochlear neuronal functional state from transcriptomic data, complementing traditional survival metrics. By prioritizing interpretable modules and standardized within-dataset scoring, CNFC supports cross-study integration and highlights candidate programmes for mechanistic testing.

Frontiers in Cellular NeuroscienceVol. 20
Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Openalex Percentile: Top 49%
Hearing, Cochlea, Tinnitus, Genetics
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