The DNA methylation landscape of naturally short-lived killifish
Annual killifish of the genus Nothobranchius are naturally short-lived vertebrates that exhibit a wide range of aging characteristics typically observed in mammals. Here, we provide the first comprehensive whole-genome methylation map for two species, revealing local age-related as well as tissue-specific dynamics in the DNA methylome. Our maps and results support the annual killifish as a model organism and further highlight its value for studying aging including possible health status predictions in vertebrates.
Authors
- Alexander Meissner (ORCID: https://orcid.org/0000-0001-8646-7469)
- Mara Steiger (ORCID: https://orcid.org/0000-0002-3747-685X)
- Alexandra M. Tyers (ORCID: https://orcid.org/0000-0002-1153-1347)
- Helene Kretzmer
- Nishita Singh
- Dario Riccardo Valenzano
Institutions
- Hasso Plattner Institute (DE)
- Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
- Max Planck Institute for Molecular Genetics (DE)
- Max Planck Institute for Biology of Ageing (DE)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1038/s41598-026-39352-3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00