Phytochemical study of <i>Homalanthus giganteus</i> : isolation, antiproliferative activity, and computational mechanistic insights of tigliane diterpenes against colorectal cancer
Six compounds were isolated from <i>H. giganteus,</i> with <b>4</b> exhibiting antiproliferative activity through PRKCA and GSK3β modulation. These findings provide the first phytochemical and mechanistic evidence that support <i>H. giganteus</i> as a promising source of active anti-colon cancer leads.
Authors
- Dyke Gita Wirasisya (ORCID: https://orcid.org/0000-0002-4829-8171)
- FR Chang
- Annamária Kincses (ORCID: https://orcid.org/0000-0002-1591-1419)
- Anita Barta
- Judit Hohmann
- Arif Setiawansyah
Institutions
- Kaohsiung Medical University (TW)
- University of Mataram (ID)
- University of Szeged (HU)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1080/13880209.2026.2629733
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00