Development and validation of a potency assay matrix for optimized and consistent manufacture of clinical mesenchymal stem/stromal cells
This potency assay platform provides a critical tool for ensuring the quality and consistency of MSC products and will facilitate clinical translation by demonstrating comparability between MSC donors as well as manufactured lots and potentially predicting therapeutic efficacy in clinical trials.
Authors
- Patrick Niekamp (ORCID: https://orcid.org/0000-0001-5485-6232)
- Erik J. Woods (ORCID: https://orcid.org/0000-0003-1431-2593)
- Brian H. Johnstone
- Dongsheng Gu
- Jie Jiang
Institutions
- Indiana University Health (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fimmu.2026.1725191
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00