Reduction of calreticulin and ERp57 with age reveals the ER stress-related roles in cell viability and organismal lifespan regulation
Taken together, our findings suggest that the age-related reduction of Calr and ERp57 may serve as a potential pro-aging biomarker, contributing to the disruption of ER homeostasis and affecting cell survival and organismal lifespan.
Authors
- Sophie Neuber-Schlicht
- Gregor Burdeos
Institutions
- Research Institute for Farm Animal Biology (FBN) (DE)
- Max Planck Institute for Biology of Ageing (DE)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fragi.2026.1758247
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yale University