Bidirectional causal associations between immune cell phenotypes and age-related macular degeneration subtypes: A mendelian randomization study
Using updated GWAS data, this study confirms subtype-specific immune associations in AMD and reports the first evidence of reverse causality: dAMD may directly modulates adaptive immune cell phenotypes. These findings refine our understanding of AMD immunopathogenesis and highlight potential targets for subtype-specific therapies.
Authors
- XinYu Jia
- Zihao Zhuang (ORCID: https://orcid.org/0000-0002-7889-4927)
- Pengcheng Hu
- Juejun Hu (ORCID: https://orcid.org/0000-0002-7233-3918)
- Haixia Lin
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1016/j.exger.2026.113074
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00