Host Response and Pathogen Load in Acanthamoeba Keratitis: A Histopathological Analysis
AK demonstrates marked variability in both organism distribution and host inflammatory response. Tissue damage appears to be more immune-mediated than organism load-dependent. Younger patients tended to show diffuse stromal involvement. Persistent cyst formation underlies recurrence, underscoring the importance of early diagnosis and prolonged postoperative anti-amoebic therapy.
Authors
- Soumya Sucharita
- Sohini Mandal
- Sujata Das
- Nihar Garg
- Smruti Rekha Priyadarshini
Institutions
- L V Prasad Eye Institute (IN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1167/iovs.67.2.36
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00