Escherichia coli BL21 adapts its central carbon metabolism to recombinant protein production and oxygen limitation
This study provides insights into metabolic adaptations in E. coli BL21 recombinant strains, having quite robust mechanisms to maintain intracellular metabolic homeostasis during both internal and external perturbations.
Authors
- Laura García-Calvo (ORCID: https://orcid.org/0000-0002-9885-9854)
- Per Bruheim (ORCID: https://orcid.org/0000-0002-7851-8083)
- Divyata Vilas Rane (ORCID: https://orcid.org/0000-0002-0754-0507)
- Karen Lund Haaland
- Hege Skuggedal
- Stinus Reklev Øverbø
- Åse Refsnes
Institutions
- Norwegian University of Science and Technology (NO)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1186/s12934-026-02924-z
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00