Chloride Intracellular Channel 4 (CLIC4) controls volume regulation in sperm development via Protein Kinase C (PKC)
CLIC4 is a key component of the sperm cell volume regulation machinery, modulating Cl fluxes during maturation. These findings provide new insights into the molecular basis of sperm osmoregulation and may inform therapeutic strategies for male infertility.
Authors
- John C. Edwards (ORCID: https://orcid.org/0000-0001-8247-0708)
- Satish K. Raut (ORCID: https://orcid.org/0000-0002-8821-1683)
- Harpreet Singh (ORCID: https://orcid.org/0000-0002-6135-1897)
- Adán Guerrero (ORCID: https://orcid.org/0000-0002-4389-5516)
- Shubha Gururaja Rao (ORCID: https://orcid.org/0000-0003-2234-1917)
- Shridhar Sanghvi (ORCID: https://orcid.org/0000-0001-9254-7078)
- Jose L de La Vega Beltran
- A. Montanez-Barragan
- Gerardo Orta
- Aaryan Patel
- Hiram Pacheco Castillo
- Veronica Loyo-Celis
- Alberto Darszon
- Santiago Partida-Sanchez
- Victor Xavier Abonza Amaro
Institutions
- Nationwide Children's Hospital (US)
- Ohio Northern University (US)
- The Ohio State University Wexner Medical Center (US)
- Centro de Ingeniería Genética y Biotecnología (CU)
- Saint Louis University (US)
- The Ohio State University (US)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- BMC Biology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1186/s12915-026-02561-3
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00