Locoregional and systemic control after total neoadjuvant therapy with short-course radiotherapy for locally advanced rectal cancer: long-term outcomes from the LARCT-US study

TNT consisting of 5 × 5 Gy followed by four cycles of CAPOX/six cycles of FOLFOX resulted in excellent locoregional and distant control, despite inclusion of more advanced tumours than previous TNT studies. The low LRR risk in LARCT-US could be explained by more adequate distal resection margins practiced at Swedish centres.

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Publication Details

Journal
British journal of surgery
Published
2026-02-19
DOI
https://doi.org/10.1093/bjs/znag014
Citations
1
Primary Topic
Colorectal Cancer Surgical Treatments
Type
article
Field-Weighted Citation Impact
24.20
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article

Locoregional and systemic control after total neoadjuvant therapy with short-course radiotherapy for locally advanced rectal cancer: long-term outcomes from the LARCT-US study

Per Nilsson, Tanweera Khan, Eva Angenete, Israa Imam et al.
1 citations
British journal of surgery
Colorectal Cancer Surgical Treatments
24.20
article

Locoregional and systemic control after total neoadjuvant therapy with short-course radiotherapy for locally advanced rectal cancer: long-term outcomes from the LARCT-US study

Per Nilsson, Tanweera Khan, Eva Angenete, Israa Imam, Bengt Glimelius
article en
1 citations

Abstract

TNT consisting of 5 × 5 Gy followed by four cycles of CAPOX/six cycles of FOLFOX resulted in excellent locoregional and distant control, despite inclusion of more advanced tumours than previous TNT studies. The low LRR risk in LARCT-US could be explained by more adequate distal resection margins practiced at Swedish centres.

British journal of surgeryVol. 113(3)
Uppsala University (SE), Karolinska University Hospital (SE), Uppsala University Hospital (SE), Sahlgrenska University Hospital (SE), Akademiska Barnsjukhuset (SE), University of Gothenburg (SE)
Openalex Percentile: Top 1%
Colorectal Cancer Surgical Treatments
24.20
DOIOpen Access PDFOpenAlex
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Locoregional and systemic control after total neoadjuvant therapy with short-course radiotherapy for locally advanced rectal cancer: long-term outcomes from the LARCT-US study — Per Nilsson, Tanweera Khan, et al. · British journal of surgery (2026) | TGRS Research Map | TGRS