The mechanism of Vicenin-2 in ameliorating skin photoaging: involvement of m6A-modified macrophage polarization
The findings indicate that Vicenin-2 may mitigate skin photoaging by modulating macrophage polarization toward the M2 phenotype through m6A-dependent regulation of the NF-κB signaling pathway, supporting its potential as a novel topical agent for photoaging intervention.
Authors
- Yunzhu Mu (ORCID: https://orcid.org/0000-0001-7680-9621)
- Wenlong Shuai (ORCID: https://orcid.org/0009-0008-9084-427X)
- Meng Chen (ORCID: https://orcid.org/0009-0005-3537-9027)
- Bowen Tan (ORCID: https://orcid.org/0000-0002-5734-1602)
- Yu Zhou (ORCID: https://orcid.org/0000-0003-1216-9893)
- Xi Duan
- Ruishan Li
- Xinyi Peng
Institutions
- North Sichuan Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fphar.2026.1778993
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund