Mapping fibrosis in colorectal liver metastases (CRLM) with gadobenate dimeglumine-enhanced MRI: prognostic implications and imaging biomarkers

Gd-BOPTA-enhanced MRI, specifically SICP and TLEI in the delayed phase, may serve as non-invasive imaging biomarkers of fibrosis in CRLM. Contrary to prior assumptions, increased fibrosis was associated with worse prognosis, suggesting fibrosis-mediated tumor microenvironment alterations. Prospective studies with robust radiologic-pathologic validation are needed to clarify the mechanistic and prognostic implications.