<i>Porphyromonas gingivalis</i> and <i>Scardovia wiggsiae</i> promote neutrophil‐induced lung epithelial cell apoptosis and emphysema
We demonstrated that the oral bacteria Porphyromonas gingivalis and Scardovia wiggsiae exacerbate ligature-induced inflammation and increase proinflammatory cytokines in local gingival crevicular fluid, systemic serum, and distal bronchoalveolar lavage, and are associated with more neutrophil infiltration in the lung. The in vivo experiment indicated that gingival infection with P. gingivalis and S. wiggsiae worsens porcine pancreatic elastase-induced pulmonary apoptosis and emphysema. Here, we show that P. gingivalis and S. wiggsiae are potential pathogenic factors for COPD.
Authors
- Chong‐Jen Yu (ORCID: https://orcid.org/0000-0001-5664-9392)
- Hsin‐Han Hou
- Chung‐Wei Wang (ORCID: https://orcid.org/0000-0001-5193-9390)
- Yen‐Ling Chu
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Chun‐Pin Lin (ORCID: https://orcid.org/0000-0002-3498-1113)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Shih‐Jung Cheng
Institutions
- National Taiwan University (TW)
- National Taipei University of Nursing and Health Science (TW)
- Chang Gung Memorial Hospital (TW)
- Taoyuan Chang Gung Memorial Hospital (TW)
- National Taiwan University Hospital (TW)
- National Yunlin University of Science and Technology (TW)
Publication Details
- Journal
- Journal of Periodontology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1002/jper.70091
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University Hospital
- National Taiwan University